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Our story

We are a large multidisciplinary group comprising researchers and clinicians, founded in 2008 and located at the Paris Brain Institute (ICM) since 2011.

We work alongside on the control of normal and abnormal movements from different angles, including behaviour, cognition and development.

Methodologically, we offer multimodal approaches combining imaging, neurophysiology, metabolic and sleep studies.

One of our major strengths is direct access to healthy volunteers and patients alike and contrasting these investigations with more basic/fundamental approaches, such as animal models and computational neuroscience.
Thanks to this broad canvas, we offer all our students and collaborators a unique research environment and work experience, both stimulating and rewarding.

Our teams

Team

Biomarkers and innovative therapies of motor deficits in stroke

Intro

Although significant advancements have been reached for the hyper acute phase of stroke, there are still issues to solve, especially after 24 hours and later: (i) the identification of biomarkers for motor recovery and, (ii) the development of new innovative strategies including non-invasive brain stimulation and e-health(digital rehab programs, Do It Yourself, etc..) approaches.

The overall goal of our team is to develop complementary approaches (coupling clinical, neuroimaging and neurophysiological methods) to address these two lines of research(biomarkers and novel innovative strategies). Elucidating the mechanisms of cerebral plasticity during motor recovery is the main component linking our two axes.

Theme 1: Identifying novel structural and functional biomarkers for stroke outcome

Theme 2: Development of innovative therapeutic approaches in recovery

Team PIs

Team

Characterization and treatment of neurometabolic dysfunction

Intro

The central question of my research group is "how to treat brain metabolic dysfunctions associated with neurological disorders?"

I have built an internationally renowned expertise in rare human diseases that primarily affect brain metabolic pathways. My group has developed an original therapeutic approach that targets the Krebs cycle in order to correct brain energy deficiency. We use various metabolic technologies (in vivo metabolic imaging, metabolomics, lipidomics) to characterize brain metabolic dysfunctions in neurodegenerative diseases.

Team PIs

Team

Dream team: sleep, dreams and cognition

Intro

Our clinical research is focused on neurological sleep disorders(hypersomnias, parasomnias, sleep in Parkinson’s disease) in order to understand their mechanisms and treat them. Our basic research aims to understand how sleep and associated dreams impact our cognitive functioning (memory, creativity, problem solving) and emotion processing. Both clinical and basic research investigate dissociated states between wake and sleep (e.g. sleep onset period, local sleep intrusions during waking, in the general population and clinical models), using neurophysiological recordings (e.g. EEG, videopolysomnography, fMRI) combined with behavioural tasks, and experience sampling. We leverage clinical models to open a window into the sleeping mind such as lucid dreaming in narcolepsy, enacted dreams in REM sleep behaviour disorder, and sleep talking in sleepwalking patients.

Team PIs

Team

Eye movement control in primates

Intro

We want to understand how the brain works. We want to understand how the wirings of billions of deterministic entities (such as the neurons in our brain) are capable to express emergent properties such as decision. In order to examine this question, we are actually applying three restrictions:

1. The species, we are examining the wirings of the brain of non-human primates.

2. The function, we are focusing on the selection, the control and the monitoring of eye movements.

3. The structures, we are studying the frontal eye field, the supplementary eye field and the anterior cingulate regions of the brain.

These restrictions in mind, we are hoping that rules, laws and principles that govern the relations between structure and function within these specific areas of the brain can be generalized across, structures, functions and species so we can understand how our brain works.

Team PIs

Team

Human neurophysiology of motor and cognitive process

Intro

Coming soon!

Team PIs

Team

Neuro-developmental disorders: motor and cognitive biomarkers, animal models and therapeutics

Intro

The central question of our research group is to explore the pathophysiology of behavioural and movement dysfunctions associated with rare diseases with developmental disorders (mirror movements) and behavioural and motor dysfunctions (dystonia/ Tourette syndrome).

We develop a common approach combining,

a) in vivo and biological study of animal models combined with non invasive explorations of the related genetic forms of human diseases and

b) multimodal neuroimaging-neurophysiology analysis of motor and non-motor cerebral networks in various phenotypes of these rare disorders with the objective to develop innovative therapeutics...

Team PIs

Team

Parkinsonism: pathophysiology, modelisation, imaging biomarkers and therapeutics using focused ultrasound

Intro

Coming soon!

Team PIs

Team

Preclinical MRI investigations of neurological diseases, biomarkers and therapeutics

Intro

Our team aims at investigating imaging strategies in experimental models. Imaging biomarkers are crucial for the diagnosis, longitudinal follow up of disease and therapeutics. The team develops in vivo and post-mortem magnetic resonance imaging protocols at very high magnetic field (11.7T) for the evaluation of rodent and small primate models of movement disorders such as Parkinson’s disease, as well as of other various neurological diseases (Alzheimer’s disease, Multiple Sclerosis, Tumours, etc…). It includes the entire pipeline for preclinical studies: data acquisition, post-processing and data analysis as well as animal handling and biological support.

Team PIs

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