Leu-Semenescu Smaranda


Interested and specialized (interuniversity degrees) in movement and neurological sleep disorders, I am a full-time neurologist inthe Sleep Department and the National reference Center for Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome at Pitié-SalpêtrièreHospital, Sorbonne Université, in Paris.

Sleep provides a valuable insight to understand movement disorders. For example, bradykinesia vanishes during sleep when patients with Parkinson disease act out their dreams, abnormal movements disappear during sleep, and reappear upon waking. One of my interests is to try to understand how sleepacts on movement control, based on clinical observations through various pathologies of movement during sleep or at the transition from sleep to wake. Secondly, I am interested to study rare hypersomnias, their clinical features and mechanisms, which has led me to focus on “hybrid states” such as hallucinations, REM sleep behaviour disorder, and other parasomnias.  

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-Kleine-Levin Syndrome is associated with birth difficulties and genetic variants in the TRANK1 gene loci. Ambati A, Hillary R, Leu-SemenescuS, Ollila HM, Arnulf I, Mignot EJ.Proc Natl Acad Sci U S A. 2021

-Sleep in ADCY5-Related Dyskinesia: Prolonged Awakenings Caused by Abnormal Movements. MéneretA, Roze E, Maranci JB, Dodet P, Doummar D, Riant F, Tranchant C, Fraix V,Anheim M, Ekmen A, McGovern E, Vidailhet M, Arnulf I, Leu-Semenescu S.J ClinSleep Med. 2019 

-Can we still dream when the mind isblank? Sleep and dream mentations in auto-activation deficit. Leu-Semenescu S, Uguccioni G, Golmard JL, Czernecki V,Yelnik J, Dubois B, Forgeot d'Arc B, Grabli D, Levy R, Arnulf I. Brain. 2013

-Hallucinations in narcolepsy with and without cataplexy: contrasts with Parkinson's disease. Leu-SemenescuS, De Cock VC, Le Masson VD, Debs R, Lavault S, Roze E, Vidailhet M, Arnulf I.Sleep Med. 2011

-The improvement of movement and speech during rapid eye movement sleep behaviour disorder in multiple system atrophy. De Cock VC, Debs R, Oudiette D, Leu S, Radji F, Tiberge M, Yu H,Bayard S, Roze E, Vidailhet M, Dauvilliers Y, Rascol O, Arnulf I. Brain. 2011

-Sleep And rhythm consequences of a genetically induced loss of serotonin. Leu-Semenescu S, Arnulf I, DecaixC, Moussa F, Clot F, Boniol C, Touitou Y, Levy R, Vidailhet M, Roze E.Sleep.2010

-Do the eyes scandream images during rapid eye movement sleep? Evidence from the rapid eye movement sleep behaviour disorder model. Leclair-Visonneau L, Oudiette D, Gaymard B, Leu-Semenescu S, Arnulf I. Brain. 2010

Restoration of normal motor control in Parkinson's disease during REM sleep. De Cock VC, Vidailhet M, Leu S, Texeira A, Apartis E, Elbaz A,Roze E, Willer JC, Derenne JP, Agid Y, Arnulf I. Brain. 2007

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